From Event: SPIE BiOS, 2020
Rupture of carotid plaques triggers stroke. Current diagnosis of stroke is based on lumen stenosis, resulting in sever overtreatment. Photoacoustic (PA) imaging can provide comprehensive and patient-specific assessment of plaque vulnerability, and prevent overtreatment. However, no in vivo PA imaging of carotid plaque is available due to low SNR. Here, we present a fast PA/US imaging system and motion corrected averaging algorithm to increase PA SNR. The imaging system and algorithm are verified ex vivo, and in vivo on patients during carotid endarterectomy (intra-operatively). The results may accelerate the clinical translation of PA imaging of carotid plaques.
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Min Wu, Elcke Vloedgraven, Roy van Hees, Jan-Willem Muller, Marc Van Sambeek, Frans van de Vosse, Richard Lopata, and Hans-Martin Schwab, "Towards in vivo PA imaging of vulnerable plaques in carotid arteries (Conference Presentation)," Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 1124005 (Presented at SPIE BiOS: February 02, 2020; Published: 20 April 2020); https://doi.org/10.1117/12.2541946.6150877876001.