We constructed multifunction nano systems and investigated the synergize photothermal and immunological effects. Here, we design new synergistic nano-particles, both have the photothermal effects and immunological effects. We investigate the therapeutic effects and detect the immune response with metastatic mouse tumor models. We also study the therapeutic mechanism after treatment in vitro and in vivo. With the enhancement of nano-materials on photothermal effects, laser treatment could destroy primary tumor and protect normal tissue with low dose laser irradiation. With the immunological effects of nano-materials, the treatment could trigger specific antitumor immune response, to eliminate the metastasis tumor. It is providing a promising treatment modality for the metastatic cancers.
Feifan Zhou and Wei R. Chen, "Photo-nano immunotherapy for metastatic cancer (Conference Presentation)," Proc. SPIE 11241, Biophotonics and Immune Responses XV, 1124106 (Presented at SPIE BiOS: February 03, 2020; Published: 6 March 2020); https://doi.org/10.1117/12.2542932.6138718619001.
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