The recent advent of Optical Photothermal IR (O-PTIR), has enabled for the first time, submicron infrared microscopy in far-field reflection mode with the combination of Raman for simultaneous and true correlative IR+Raman microscopy. These unique and exciting synergistic capabilities are now spawning interest in life science application . In this presentation, examples of life science applications, ranging from live cell imaging of epithelial cheek cells in water, with submicron resolution of organelles, single bacteria IR imaging to ultra-high resolution images of breast tissue calcifications showing previously unknown levels of heterogeneity of calcifications that with traditional FTIR/QCL microscopes are not possible.
Mustafa Kansiz and Craig Prater, "Super resolution correlative far-field submicron simultaneous IR and raman microscopy: a new paradigm in vibrational spectroscopy," Proc. SPIE 11252, Advanced Chemical Microscopy for Life Science and Translational Medicine, 112520E (Presented at SPIE BiOS: February 01, 2020; Published: 10 March 2020); https://doi.org/10.1117/12.2565489.6138730519001.
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