The results of expanded spectral analysis of donor bone implants using the Raman spectroscopy method are presented in the work. Mathematical methods of improving resolution of spectral contours and chemometric analysis are used for evaluation of component composition of the implants. It is shown that the Raman spectroscopy can be used for evaluation of relative concentration of mineral and organic components in extracellular matrix of bone tissue. Spectral features of the samples of bone tissues demineralized and processed with ultrasound with different degree are found as a result of the study. The criteria allowing evaluating the component composition during manufacture of bioimplants are suggested in the work.
P. E. Timchenko, E. V. Timchenko, L. T. Volova, and O. O. Frolov, "Chemometric analysis of bioimplants of bone tissues during their manufacture," Proc. SPIE 11363, Tissue Optics and Photonics, 113632A (Presented at SPIE Photonics Europe: April 09, 2020; Published: 2 April 2020); https://doi.org/10.1117/12.2565723.
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