From Event: SPIE Photonex, 2021
We are exploring the use of different optical regions in the Mid-infrared (Mid-IR) that can be used to develop future point
of care tools and methodologies. This research will allow us to establish new methods to monitor proxies for health within
blood samples. Mid-IR spectra of heme groups were studied by FTIR analysis to find spectral signatures can be exploited
to quantify the redox state of haemoglobin as a function of its concentration. We performed Attenuated Total Reflection
Spectroscopy (ATR) using heme groups. We found spectral differences between HbMet and Hb/HbO2 in the regions
3000-3600, 2000-2100 and 1300 cm-1. Mid-IR has the potential to expand the optical tools in medical monitoring and
diagnosis for future non-invasive characterization systems. This could open a window of opportunity to understand proxies
for disease and health in blood.
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Victor Ochoa-Gutierrez, Mauro Pazmino-Betancourth, Julien Reboud, Andrew R. Harvey, and Jonathan M. Cooper, "Analysis and exploration of heme groups using ATR-FTIR for future health monitoring," Proc. SPIE 11879, Frontiers in Biophotonics and Imaging, 1187905 (Presented at SPIE Photonex: September 29, 2021; Published: 6 October 2021); https://doi.org/10.1117/12.2598646.