Nanoparticles in the single digit nanometer range can be easily isolated and studied with low optical powers using nanoaperture tweezers. We have studied individual proteins and their interactions with small molecules, DNA and antibodies. Recently, using the fluctuations of the trapped object, we have pioneered a new way to "listen" to the vibrations of nanoparticles in the 100 GHz - 1 THz range; the approach is called extraordinary acoustic Raman (EAR). EAR gives unprecedented low frequency spectra of individual proteins in solution, allowing for identification and analysis, as well as probing their role in biological functions. We have also used EAR to study the elastic properties, shape and size of various individual nanoparticles.
Reuven Gordon, "Nano-bio-optomechanics: nanoaperture tweezers probe single nanoparticles, proteins, and their interactions," Proc. SPIE 9544, Metamaterials, Metadevices, and Metasystems 2015, 954403 (Presented at SPIE Nanoscience + Engineering: August 10, 2015; Published: 1 September 2015); https://doi.org/10.1117/12.2193785.
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