We have developed a super fast intravascular optical coherence tomography (OCT) system called Heartbeat OCT. Heartbeat OCT relies on a Fourier Domain Mode Locked (FDML) laser and a micro-motor based catheter. The system enables acquisition of a uniformly sampled data set within one cardiac cycle, triggered by the ECG, to restore 3D OCT image fidelity. Here, we present a robust and easy to operate preclinical prototype system for interventional imaging which greatly facilitates data acquisition. The new system is using a fully automatic 1.6 MHz turnkey FDML laser with increased stability. The entire system was mounted into a 1.6 x 0.8 x 0.7 m cart. It is coupled to a guidewire compatible rapid-exchange catheter that can be used for routine imaging. The system is robust, compact, and moveable. We present the design, demonstrate ex-vivo imaging results and discuss in-vivo applications, as well as considerations for clinical translation of the technology. The ex-vivo imaging experiments were conducted with metal stents and bioresorbable vascular scaffold. The images provide clear and comprehensive visualization of the stents structure not only in cross-section but also in longitudinal rendering and 3D construction.
Tianshi Wang, Tom Pfeiffer, Wolfgang Wieser, Evelyn Regar M.D., Charles T. Lancee, Geert Springeling, Antonius F. W. van der Steen, Robert Huber, and Gijs van Soest, "Heartbeat OCT: a new tool for interventional imaging (Conference Presentation)," Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 96892M (Presented at SPIE BiOS: February 13, 2016; Published: 27 April 2016); https://doi.org/10.1117/12.2212929.4828143217001.
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