Intravascular optical coherence tomography (IVOCT) is an intravascular imaging modality which enables the visualization arterial structures at the micro-structural level. The interpretations of these structures is mainly on the basis of relative image intensities. However, even for homogeneous tissue light intensities can differ. In this study the incident light intensity is modeled to be related to the catheter position. Two factors, the distance between catheter and inner lumen wall as well as the incident angle of the light upon the lumen wall, are considered. A three-level hierarchical model is constructed to statistically validate this model to include the potential effect of different pullbacks and/or frame numbers. The model is solved using 169 images out of 9 pull-backs recorded with a St.Jude Medical IVOCT system. F-tests results indicate that both the distance and the incident angle contribute to the model statistically significantly with p < 0.001. Based on the results from the statistical analysis, a potential compensation method is introduced to normalize the IVOCT intensities for the catheter position effects and small shadows.
Shengnan Liu, Jeroen Eggermont, Ron Wolterbeek, Boudewijn P. F. Lelieveldy, and Jouke Dijkstra, "Influence of distance and incident angle on light intensities in intravascular optical coherence tomography pullback runs," Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 96893B (Presented at SPIE BiOS: February 14, 2016; Published: 29 February 2016); https://doi.org/10.1117/12.2212472.
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