We combined cross-polarization optical coherence tomography (CP OCT) and non-linear microscopy based on second
harmonic generation (SHG) and two-photon-excited fluorescence (2PEF) to assess collagen and elastin fibers in the
development of the atherosclerotic plaque (AP). The study shows potential of CP OCT for the assessment of collagen
and elastin fibers condition in atherosclerotic arteries. Specifically, the additional information afforded by CP OCT,
related to birefringence and cross-scattering properties of arterial tissues, may improve the robustness and accuracy of
assessment about the microstructure and composition of the plaque for different stages of atherosclerosis.
Ekaterina V. Gubarkova, Varvara V. Dudenkova, Felix I. Feldchtein, Lidia B. Timofeeva, Elena B. Kiseleva, Sergei S. Kuznetsov, Alexander A. Moiseev, Gregory V. Gelikonov, Alex I. Vitkin, and Natalia D. Gladkova, "Characterization of atherosclerotic plaques by cross-polarization optical coherence tomography," Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 96893F (Presented at SPIE BiOS: February 14, 2016; Published: 29 February 2016); https://doi.org/10.1117/12.2210822.
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