Bone marrow lesions (BMLs) is an incidence-increasing disease which seriously hazard to human health and possibly
contribute to paralysis. Delayed treatment often occurred to BMLs patients due to its characteristics such as complex and
diverse clinical manifestations, non-specific, easy to misdiagnosis and etc. The conventional diagnosis methods of BMLs
mainly rely on bone marrow biopsy/aspiration, which are invasive, painful, high health risk, and discontinuous which
disabled monitoring and during-surgery guidance. Thus we proposed to develop a noninvasive, real-time, continuous
measurement, easy-operated device aimed at detecting bone marrow diseases. This device is based on near-infrared
spectroscopy and the probe is designed with a cross-shape to tightly and comfortably attach human spine. Space-resolved
source-detector placement and measurement algorithm are employed. Four selected wavelength were utilized here to
extract BMLs-related component contents of oxy-, deoxy-hemoglobin, fat, scattering index corresponding to fibrosis. We
carried out an ink experiment and one clinical measurement to verify the feasibility of our device. The potential of NIRS
in BMLs clinics is revealed.
Yu Su and Ting Li, "A portable cross-shape near-infrared spectroscopic detector for bone marrow lesions diagnosis," Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 96894K (Presented at SPIE BiOS: February 13, 2016; Published: 29 February 2016); https://doi.org/10.1117/12.2210832.
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