Deep brain stimulation’s effectiveness relies on the ability of the stimulating electrode to be properly placed within a specific target area of the brain. Optical guidance techniques that can increase the accuracy of the procedure, without causing any additional harm, are therefore of great interest.
We have designed a cheap optical fiber-based device that is small enough to be placed within commercially available DBS stimulating electrodes’ hollow cores and that is capable of sensing biological information from the surrounding tissue, using low power white light. With this probe we have shown the ability to distinguish white and grey matter as well as blood vessels, in vitro, in human brain samples and in vivo, in rats. We have also repeated the in vitro procedure with the probe inserted in a DBS stimulating electrode and found the results were in good agreement.
We are currently validating a second fiber optic device, with micro-optical components, that will result in label free, molecular level sensing capabilities, using CARS spectroscopy. The final objective will be to use this data in real time, during deep brain stimulation neurosurgery, to increase the safety and accuracy of the procedure.
Damon T. DePaoli, Nicolas Lapointe, Laurent Goetz, Martin Parent, Michel Prudhomme, Léo Cantin, Tigran Galstian, Younès Messaddeq, and Daniel C. Côté, "Fiber-based tissue identification for electrode placement in deep brain stimulation neurosurgery
(Conference Presentation)," Proc. SPIE 9690, Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation, 96900G (Presented at SPIE BiOS: February 13, 2016; Published: 26 April 2016); https://doi.org/10.1117/12.2213353.4848636545001.
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