The development of nosocomial ventilator-associated pneumonia (VAP) has been linked to the presence of specific
bacteria found in the biofilm that develops in intubated endotracheal tubes of critical care patients. Presence of biofilm
has been difficult to assess clinically. Here, we use Optical coherence tomography (OCT), to visualize the biofilm at both
the proximal and distal tips. Ultimately, the goal will be to determine if OCT can be a tool to visualize biofilm
development and potential interventions to reduce the incidence of VAP.
Robert E. Dunn, Andrew E. Heidari, Samer Moghaddam M.D., Mengke Zhang, Changhoon Han, Kyung-Jin Oh, Steve Leven, Matthew Brenner M.D., Carl Genberg, and Zhongping Chen, "Optical coherence tomography imaging to analyze biofilm thickness from distal to proximal regions of the endotracheal tubes," Proc. SPIE 9691, Endoscopic Microscopy XI; and Optical Techniques in Pulmonary Medicine III, 96911G (Presented at SPIE BiOS: February 14, 2016; Published: 8 March 2016); https://doi.org/10.1117/12.2213247.
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