Keratoconus is an ophthalmic disease in which the cornea acquires an abnormal conical shape that prevents the correct
focusing on the retina, causing visual impairment. The late diagnosis of keratoconus is among the principal causes of
corneal transplantation surgery. In this study, we characterize the morphology of keratoconic corneas by means of the
correlation of SHG images, finding that keratoconus can be diagnosed by analyzing the inclination of lamellae below
Bowman’s membrane. In addition, imaging performed with both sagittal and “en face” geometry demonstrated that this
morphological features can be highlighted both ex vivo and in vivo.
R. Mercatelli, F. Ratto, F. Tatini, F. Rossi, L. Menabuoni, R. Nicoletti, R. Pini, Frederick Pavone, and R. Cicchi, "Morphological characterization of keratoconus-affected human corneas by SHG imaging and correlation analysis," Proc. SPIE 9693, Ophthalmic Technologies XXVI, 96930Y (Presented at SPIE BiOS: February 14, 2016; Published: 4 March 2016); https://doi.org/10.1117/12.2209618.
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