This paper highlights the methodology in measuring interstitial pressure in pancreatic adenocarcinoma tumors. A Millar
Mikrotip pressure catheter (SPR-671) was used in this study and a system was built to amplify and filter the output signal
for data collection. The Millar pressure catheter was calibrated prior to each experiment in a water column at 37°C, range
of 0 to 60 inH2O (112 mmHg), resulting in a calibration factor of 33 mV / 1 inH2O. The interstitial pressures measured in
two orthotopically grown pancreatic adenocarcinoma tumor were 57 mmHg and 48 mmHg, respectively. Verteporfin
uptake into the pancreatic adenocarcinoma tumor was measured using a probe-based experimental dosimeter.
Michael D. Nieskoski, Jason Gunn, Kayla Marra, B. Stuart Trembly, and Brian W. Pogue, "Pancreas tumor interstitial pressure catheter measurement," Proc. SPIE 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV, 969408 (Presented at SPIE BiOS: February 13, 2016; Published: 5 April 2016); https://doi.org/10.1117/12.2214181.
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