PDT dose is the product of the photosensitizer concentration and the light fluence in the target tissue. For improved
dosimetry during plural photodynamic therapy (PDT), a PDT dose dosimeter was developed to measure both the
light fluence and the photosensitizer concentration simultaneously in the same treatment location. Light fluence and
spectral data were rigorously compared to other methods of measurement (e.g. photodiode, multi-fiber spectroscopy
contact probe) to assess the accuracy of the measurements as well as their uncertainty. Photosensitizer concentration
was obtained by measuring the fluorescence of the sensitizer excited by the treatment light. Fluence rate based on
the intensity of the laser spectrum was compared to the data obtained by direct measurement of fluence rate by a
fiber-coupled photodiode. Phantom studies were done to obtain an optical property correction for the fluorescence
signal. Measurements were performed in patients treated Photofrin for different locations in the pleural cavity.
Multiple sites were measured to investigate the heterogeneity of the cavity and to provide cross-validation via
relative dosimetry. This novel method will allow for accurate real-time determination of delivered PDT dose and
improved PDT dosimetry.
Michele M. Kim, Arash Darafsheh, Mahmoud Ahmad, Jarod C. Finlay, and Timothy C. Zhu, "PDT dose dosimeter for pleural photodynamic therapy," Proc. SPIE 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV, 96940Y (Presented at SPIE BiOS: February 15, 2016; Published: 17 March 2016); https://doi.org/10.1117/12.2213401.
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