With 50% of all interventional procedures in the US being minimally invasive, there is a need for objective tools to help guide surgeons in this challenging environment. Tissue oxygenation is a useful biomarker of tissue viability and suitable for surgical guidance. Here we present our efforts to perform real-time quantitative optical imaging through a rigid endoscope using Single Snapshot of Optical Properties (SSOP) imaging. In particular, in this work we introduce for the first time 3 dimensionally-corrected dual wavelength optical properties imaging using SSOP through an endoscope, allowing accurate oxygenation maps to be obtained on tissue simulating phantoms and in vivo samples. We compared the results with state-of-the-art wide-field spatial frequency domain imaging (SFDI). Overall, results from the novel endoscopic imaging system agreed within 10% in absorption, reduced scattering, and oxygenation. Moreover, we introduce here real-time, video-rate quantitative optical imaging with 3D profile correction through an endoscope. These results demonstrate the potential of endoscopic SSOP as an objective surgical guidance tool for the clinic.
Joseph P. Angelo, Martijn van de Giessen, and Sylvain Gioux, "Real-time endoscopic oxygenation imaging using single snapshot of optical properties (SSOP) imaging
(Conference Presentation)," Proc. SPIE 9696, Molecular-Guided Surgery: Molecules, Devices, and Applications II, 969605 (Presented at SPIE BiOS: February 13, 2016; Published: 26 April 2016); https://doi.org/10.1117/12.2213117.4848635749001.
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