Residual tumor deposits missed by conventional treatments frequently seed local and distal recurrence utilizing a network of molecular signaling mechanisms. Beyond providing contrast for molecular-guided surgery, this talk will highlight new concepts in phototherapy to address residual cancer cells in danger zones of recurrence, including selective treatment of microscopic disease using molecular-targeted, activatable immunoconjugates, and photo-initiated release of multikinase inhibitors that suppress multiple modes of tumor escape using optically active nanoparticles. These new approaches support an expanded role for the use of light in fluorescence-guided surgery—for phototherapy and for focused drug release to maximize tumor debulking with suppression of disease recurrence.
Bryan Q. Spring, R. Bryan Sears, Lei Z. Zheng, Zhiming Mai, Reika Watanabe, Elizabeth Villa, and Tayyaba Hasan, "Optical probes for molecular-guided surgery: Using photomedicine to prevent recurrence in the surgical bed
(Conference Presentation)," Proc. SPIE 9696, Molecular-Guided Surgery: Molecules, Devices, and Applications II, 96960B (Presented at SPIE BiOS: February 13, 2016; Published: 26 April 2016); https://doi.org/10.1117/12.2213885.4848635730001.
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