The success of optical surgical navigation depends upon being able to intraoperatively employ a contrast agent and an imaging device to successfully guide surgery. Development of devices and contrast agents typically occur separately even though it is their combined performance that ultimately determines success and clinical adoption. Herein, we review critical issues and summarize our strategies and approaches for validating molecularly-targeted, near-infrared fluorescent contrast agents and the devices sufficiently sensitive enough for their detection in order to guide lymph node dissection.
Eva M. Sevick-Muraca, Barrett R. Harvey, John C. Rasmussen, and Banghe Zhu, "Optical surgical navigation for nodal staging: to see or not to see?," Proc. SPIE 9696, Molecular-Guided Surgery: Molecules, Devices, and Applications II, 96960G (Presented at SPIE BiOS: February 14, 2016; Published: 4 March 2016); https://doi.org/10.1117/12.2224851.
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