Morbidity and complexity involved in lymph node staging via surgical resection and biopsy calls for staging techniques that are less invasive. While visible blue dyes are commonly used in locating sentinel lymph nodes, since they follow tumor-draining lymphatic vessels, they do not provide a metric to evaluate presence of cancer. An area of active research is to use fluorescent dyes to assess tumor burden of sentinel and secondary lymph nodes. The goal of this work was to successfully perform fluorescence imaging of IRDye®680RD in the lymphatics, in a repeatable manner.
Alisha V. DSouza, Kayla A. Marra, Jason R. Gunn, Kimberley S. Samkoe, Kenneth M. Tichauer, and Brian W. Pogue, "Methods for effective fluorophore injection and imaging of lymphatics in small animals," Proc. SPIE 9696, Molecular-Guided Surgery: Molecules, Devices, and Applications II, 96960W (Presented at SPIE BiOS: February 14, 2016; Published: 4 March 2016); https://doi.org/10.1117/12.2213675.
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