In this study, we present an angiographic system comprised from a novel 18.9 MHz swept wavelength source integrated with a MEMs-based 23.7 kHz fast-axis scanner. The system provides rapid acquisition of frames and volumes on which a range of Doppler and intensity-based angiographic analyses can be performed. Interestingly, the source and data acquisition computer can be directly phase-locked to provide an intrinsically phase stable imaging system supporting Doppler measurements without the need for individual A-line triggers or post-processing phase calibration algorithms. The system is integrated with a 1.8 Gigasample (GS) per second acquisition card supporting continuous acquisition to computer RAM for 10 seconds. Using this system, we demonstrate phase-stable acquisitions across volumes acquired at 60 Hz frequency. We also highlight the ability to perform c-mode angiography providing volume perfusion measurements with 30 Hz temporal resolution. Ultimately, the speed and phase-stability of this laser and MEMs scanner platform can be leveraged to accelerate OCT-based angiography and both phase-sensitive and phase-insensitive extraction of blood flow velocity.
Serhat Tozburun, Cedric Blatter, Meena Siddiqui, Ahhyun S Nam, and Benjamin J Vakoc, "Angiographic imaging using an 18.9 MHz swept-wavelength laser that is phase-locked to the data acquisition clock and resonant scanners
(Conference Presentation)," Proc. SPIE 9697, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX, 969708 (Presented at SPIE BiOS: February 15, 2016; Published: 26 April 2016); https://doi.org/10.1117/12.2214775.4848635717001.
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