Currently, cardiac radiofrequency ablation is guided by indirect signals. We demonstrate an integrated radiofrequency ablation (RFA) and optical coherence tomography (OCT) probe for directly monitoring of the RFA procedure with OCT images in real time. The integrated RFA/OCT probe is modified from a standard commercial RFA catheter, and a newly designed and fabricated miniature forward-viewing cone-scanning OCT probe is integrated into the modified probe. The OCT system is verified with the human finger images, and the results show the integrated RFA/OCT probe can acquire high quality OCT images. The radiofrequency energy delivering function of the integrated probe is verified by comparing the RFA lesion sizes with standard commercial RFA probe. For the standard commercial probe, the average width and depth of the 10 lesions were 3.5 mm and 1.8 mm respectively. For the integrated RFA/OCT probe, the average width and depth of the 10 lesions were 3.6 mm and 1.7 mm respectively. The lesions created by the two probes are indistinguishable in size. This demonstrates that our glass window in the integrated probe has little effect on the RF energy delivery. And the integrated probe is used to monitoring the cardiac RFA procedure in real time. The results show that the RFA lesion formation can be confirmed by the loss of birefringence in the heart tissue. The system can potentially in vivo image of the cardiac wall to aid RFA therapy for cardiac arrhythmias.
Xiaoyong Fu, Colin Blumenthal, Deniz Dosluoglu, Yves T. Wang, Michael W. Jenkins, Rakesh Souza, Christopher Snyder, Mauricio Arruda, and Andrew M. Rollins, "Integrated RFA/OCT catheter for real-time guidance of cardiac RFA therapy
(Conference Presentation)," Proc. SPIE 9697, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX, 969709 (Presented at SPIE BiOS: February 15, 2016; Published: 26 April 2016); https://doi.org/10.1117/12.2214625.4848635725001.
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