Adaptive optics concepts have been applied to the advancement of biological imaging and microscopy. In particular,
AO has also been very successfully applied to cellular resolution imaging of the retina, enabling visualization of the
characteristic mosaic patterns of the outer retinal layers using flood illumination fundus photography, Scanning Laser
Ophthalmoscopy (SLO), and Optical Coherence Tomography (OCT). Despite the high quality of the in vivo images,
there has been a limited uptake of AO imaging into the clinical environment. The high resolution afforded by AO comes
at the price of limited field of view and specialized equipment. The implementation of a typical adaptive optics imaging
system results in a relatively large and complex optical setup. The wavefront measurement is commonly performed using
a Hartmann-Shack Wavefront Sensor (HS-WFS) placed at an image plane that is optically conjugated to the eye’s pupil.
The deformable mirror is also placed at a conjugate plane, relaying the wavefront corrections to the pupil. Due to the
sensitivity of the HS-WFS to back-reflections, the imaging system is commonly constructed from spherical mirrors.
In this project, we present a novel adaptive optics OCT retinal imaging system with significant potential to overcome
many of the barriers to integration with a clinical environment. We describe in detail the implementation of a compact
lens based wavefront sensorless adaptive optics (WSAO) 1060nm swept source OCT human retinal imaging system with
dual deformable lenses, and present retinal images acquired in vivo from research volunteers.
Yifan Jian, Sujin Lee, Michelle Cua, Dongkai Miao, Stefano Bonora, Robert J. Zawadzki, and Marinko V. Sarunic, "Adaptive optics OCT using 1060nm swept source and dual deformable lenses for human retinal imaging," Proc. SPIE 9697, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX, 96970W (Presented at SPIE BiOS: February 16, 2016; Published: 8 March 2016); https://doi.org/10.1117/12.2213534.
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