Research about the cutaneous burn was separated by assessment of burn depth and development of wound healing therapy. Various in vivo optical techniques were used to determined burn depth and observe the wound healing process. In this paper, we report the usage of multimodal optical coherence tomography system, which containing angiographic and polarization sensitive OCT (PS-OCT) with conventional OCT system, at burn studies. Burn was induced at 4 different degrees by control the attachment time of 75 Celsius degree heated brass rod at dorsal skin of the rat. For the burn depth assessment, we imaged the different burn degrees area. Changes of polarization sensitive signal were providing burn depth information. To see the wound healing process, each wound area imaged at long period. Conventional OCT shows the structural information about the tissue, like layer and hair follicle. Angiographic OCT provides vascular distribution and diameter of blood vessel information and PS-OCT shows birefringence tissue information. Based on the multimodal OCT data, burn depth assessment were well matched with burn induced time and wound healing process was consistent with previous wound healing report. Therefore, the multimodal OCT holds potential for burn study.
Bumju Kim, Yeorum Yoon, Viet-Hoan Le, Calvin J. Yoon, and Ki Hean Kim, "In-vivo cutaneous burn characterization and scar assay with multi-functional optical coherence tomography
(Conference Presentation)," Proc. SPIE 9697, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX, 96971C (Presented at SPIE BiOS: February 16, 2016; Published: 26 April 2016); https://doi.org/10.1117/12.2214817.4848635699001.
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