Skin blood microcirculation and the metabolism activity of tissue were examined on the patients with type 2 diabetes. Laser Doppler flowmetry (LDF) with 1064 nm laser light source and fluorescence spectroscopy (FS) with excitation light of 365 nm and 450 nm have been used to monitor the blood perfusion and the content of coenzymes NADH and FAD. Concluding, the proposed combined LDF and tissue FS approach allows to identify the significant violations in the blood microcirculation and metabolic activity for type 2 diabetes patients.
Victor V. Dremin, Victor V. Sidorov, Alexander I. Krupatkin, Gagik R. Galstyan, Irina N. Novikova, Angelina I. Zherebtsova, Evgeny A. Zherebtsov, Andrey V. Dunaev, Zera N. Abdulvapova, Karina S. Litvinova, Ilya E. Rafailov, Sergei G. Sokolovski, and Edik U. Rafailov, "The blood perfusion and NADH/FAD content combined analysis in patients with diabetes foot," Proc. SPIE 9698, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIV, 969810 (Presented at SPIE BiOS: February 16, 2016; Published: 7 March 2016); https://doi.org/10.1117/12.2212758.
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