In this paper, we demonstrate utilization of a commercial flatbed document scanner as a label-free biosensor for highthroughput imaging of DNA and protein microarrays. We implemented an interferometric sensing technique through use of a silicon/oxide layered substrate, and easy to implement hardware modifications such as re-aligning moving parts and inserting a custom made sample plate. With a cost as low as 100USD, powered by a USB cable, and scan speed of 30 seconds for a 4mm x 4 mm area with ~10μm lateral resolution, the presented system offers a super low cost, easy to use alternative to commercially available label-free systems.
Ugur Aygun, Oguzhan Avci, Elif Seymour, Derin D. Sevenler, Hakan Urey, M. Selim Ünlü, and Ayca Yalcin Ozkumur, "Low cost flatbed scanner label-free biosensor," Proc. SPIE 9699, Optics and Biophotonics in Low-Resource Settings II, 969906 (Presented at SPIE BiOS: February 13, 2016; Published: 7 March 2016); https://doi.org/10.1117/12.2214113.
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