We present a unique confocal microscope capable of measuring the Raman and Brillouin spectra simultaneously from a single spatial location. Raman and Brillouin scattering offer complementary information about a material's chemical and mechanical structure, respectively, and concurrent monitoring of both of these spectra would set a new standard for material characterization. We achieve this by applying recent innovations in Brillouin spectroscopy that reduce the necessary acquisition times to durations comparable to conventional Raman spectroscopy while attaining a high level of spectral accuracy. To demonstrate the potential of the system, we apply this system for imaging melanoma, arteriosclerotic plaque, embryonic development, bones and biomaterials. The developed instrument has the potential for very diverse analytical applications in basic biomedical science and biomedical diagnostics and imaging.
Vladislav V. Yakovlev, "Dual Raman-Brillouin microscope for chemical and mechanical characterization and imaging
(Conference Presentation)," Proc. SPIE 9701, Multimodal Biomedical Imaging XI, 97010A (Presented at SPIE BiOS: February 13, 2016; Published: 3 May 2016); https://doi.org/10.1117/12.2213691.4868251499001.
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