In this work, we present multimodal imaging of peripheral airways in vivo using an endoscopic imaging system capable of co-registered optical coherence tomography and autofluorescence imaging (OCT-AFI). This system employs a 0.9 mm diameter double-clad fiber optic-based catheter for endoscopic imaging of small peripheral airways. Optical coherence tomography (OCT) can visualize detailed airway morphology in the lung periphery and autofluorescence imaging (AFI) can visualize fluorescent tissue components such as collagen and elastin, improving the detection of airway lesions. Results from in vivo imaging of 40 patients indicate that OCT and AFI offer complementary information that may increase the ability to identify pulmonary nodules in the lung periphery and improve the safety of biopsy collection by identifying large blood vessels. AFI can rapidly visualize in vivo vascular networks using fast scanning parameters resulting in vascular-sensitive imaging with less breathing/cardiac motion artifacts compared to Doppler OCT imaging. By providing complementary information about structure and function of tissue, OCT-AFI may improve site selection during biopsy collection in the lung periphery.
Hamid Pahlevaninezhad, Anthony Lee, Geoffrey Hohert, Carley Schwartz, Tawimas Shaipanich, Alexander J. Ritchie, Wei Zhang, Calum E. MacAulay, Stephen Lam, and Pierre M. Lane, "Endoscopic high-resolution auto fluorescence imaging and optical coherence tomography of airways in vivo
(Conference Presentation)," Proc. SPIE 9701, Multimodal Biomedical Imaging XI, 97010D (Presented at SPIE BiOS: February 13, 2016; Published: 26 April 2016); https://doi.org/10.1117/12.2209726.4848643182001.
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