Nanoscale patterned structures composed of biomaterials exhibit great potential for the fabrication of functional biostructures. In this paper, we report cost-effective, rapid, and highly reproducible soft lithographic transfer-molding techniques for creating periodic micro- and nano-scale textures on poly (L-lactic acid) (PLLA) surface. These artificial textures can increase the overall surface area and change the release dynamics of the therapeutic agents coated on it. Specifically, we use the double replication technique in which the master pattern is first transferred to the PDMS mold and the pattern on PDMS is then transferred to the PLLA films through drop-casting as well as nano-imprinting. The ensuing comparison studies reveal that the drop-cast PLLA allows pattern transfer at higher levels of fidelity, enabling the realization of nano-hole and nano-cone arrays with pitch down to ~700 nm. The nano-patterned PLLA film was then coated with rapamycin to make it drug-eluting.
Rabin Dhakal, Akshit Peer, Rana Biswas, and Jaeyoun Kim, "Transfer molding processes for nanoscale patterning of poly-L-lactic acid (PLLA) films," Proc. SPIE 9705, Microfluidics, BioMEMS, and Medical Microsystems XIV, 970509 (Presented at SPIE BiOS: February 14, 2016; Published: 18 March 2016); https://doi.org/10.1117/12.2212871.
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