This paper details the development of a three dimensional (3D) printing system with a modified microfluidic printhead used for the generation of complex vascular tissue scaffolds. The print-head features an integrated coaxial nozzle that allows the fabrication of hollow, calcium-polymerized alginate tubes that can easily be patterned using 3Dbioprinting techniques. This microfluidic design allows the incorporation of a wide range of scaffold materials as well as biological constituents such as cells, growth factors, and ECM material. With this setup, gel constructs with embedded arrays of hollow channels can be created and used as a potential substitute for blood vessel networks.
P. Ravi Selvaganapathy and Rana Attalla, "Microfluidic vascular channels in gels using commercial 3D printers," Proc. SPIE 9705, Microfluidics, BioMEMS, and Medical Microsystems XIV, 97050J (Presented at SPIE BiOS: February 14, 2016; Published: 18 March 2016); https://doi.org/10.1117/12.2218401.
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