Current microfluidics-enabled point-of-care diagnostic systems are typically designed specifically for one assay type, e.g. a molecular diagnostic assay for a single disease of a class of diseases. This approach often leads to high development cost and a significant training requirement for users of different instruments. We have developed an open platform diagnostic system which allows to run molecular, immunological and clinical assays on a single instrument platform with a standardized microfluidic cartridge architecture in an automated sample-in answer-out fashion. As examples, a molecular diagnostic assay for tuberculosis, an immunoassay for HIV p24 and a clinical chemistry assay for ALT liver function have been developed and results of their pre-clinical validation are presented.
Holger Becker, Richard Klemm, William Dietze, Wallace White, Nadine Hlawatsch, Susanne Freyberg, Christian Moche, Peter Dailey, and Claudia Gärtner, "Modular microfluidic cartridge-based universal diagnostic system for global health applications," Proc. SPIE 9705, Microfluidics, BioMEMS, and Medical Microsystems XIV, 970514 (Presented at SPIE BiOS: February 15, 2016; Published: 18 March 2016); https://doi.org/10.1117/12.2217892.
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Study of self-shadowing effect as a simple means to realize nanostructured thin films and layers with special attentions to birefringent obliquely deposited thin films and photo-luminescent porous silicon