We present a multimodal optical setup, allowing non-contact photoacoustic imaging, optical coherence tomography (OCT), and non-contact mid-infrared photoacoustic spectroscopy. Photoacoustic signals are generated using a Nd:YAG laser and a tunable quantum cascade laser for photoacoustic imaging and spectroscopy, respectively. Photoacoustic signals are acquired by measuring the surface displacement of a specimen using a fiber-optic Mach-Zehnder interferometer. In the same fiber-optic network a spectral-domain OCT system is realized. Light from the photoacoustic detection laser and the OCT source are multiplexed into one fiber and the same objective is used for both imaging modalities. Light reflected from specimens is demultiplexed and guided to the respective imaging systems. To allow fast non-contact PAI and OCT imaging the detection spot is scanned across the specimens’ surface using a galvanometer scanner. As the same fiber-network and optical components are used for photoacoustic and OCT imaging the obtained images are co-registered intrinsically. Imaging is demonstrated on tissue mimicking and biological samples; spectral information is obtained for polystyrene and hemoglobin.
E. Leiss-Holzinger, M. Brandstetter, G. Langer, A. Buchsbaum, P. Burgholzer, B. Lendl, and T. Berer, "Multimodal system for non-contact photoacoustic imaging, optical coherence tomography, and mid-infrared photoacoustic spectroscopy," Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 970810 (Presented at SPIE BiOS: February 15, 2016; Published: 15 March 2016); https://doi.org/10.1117/12.2212411.
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