In deep photoacoustic imaging, resolution is inherently limited by acoustic diffraction, and ultrasonic frequencies cannot be arbitrarily increased because of attenuation in tissue. Here we report on the use of multiple speckle illumination to perform super resolution photoacoustic imaging. We show that the analysis of speckle-induced second-order fluctuations of the photoacoustic signal combined with deconvolution enables to resolve optically absorbing structures below the acoustic diffraction limit.
Thomas Chaigne, Jérôme Gateau, Marc Allain, Ori Katz, Sylvain Gigan, Anne Sentenac, and Emmanuel Bossy, "Breaking the acoustic diffraction limit in photoacoustic imaging with multiple speckle illumination," Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97081P (Presented at SPIE BiOS: February 16, 2016; Published: 18 March 2016); https://doi.org/10.1117/12.2212928.
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