We report a novel hybrid method of robust strain mapping in compressional optical coherence elastography using combined phase measurements on sub-wavelength-scale and cumulative pixel-scale displacement tracking. This hybrid nature significantly extends the range of measurable displacements and strains in comparison with conventional direct phase-resolved measurements. As a result, the proposed strain-mapping method exhibits significantly increased robustness with respect to both additive noise and decorrelation noise produced by displacements and strains. The main advantages of the proposed approach are illustrated by numerical simulations. Experimental examples of obtained strain maps for phantoms and real biological tissues are also presented.
Vladimir Y. Zaitsev, Alexander L. Matveyev, Lev A. Matveev, Grigory V. Gelikonov, Ekaterina Gubarkova, Natalia D. Gladkova, and Alex Vitkin, "Robust strain mapping in optical coherence elastography by combining local phase-resolved measurements and cumulative displacement tracking," Proc. SPIE 9710, Optical Elastography and Tissue Biomechanics III, 97100O (Presented at SPIE BiOS: February 14, 2016; Published: 15 March 2016); https://doi.org/10.1117/12.2211117.
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