Quantitative elastography is a power technique to detect and analyze the changes in biomedical properties of tissues in normal and pathological states. In this study, two noncontact elastography techniques, laser Michelson vibrometry (LMV) and optical coherence elastography (OCE), were utilized to quantify the Young’s modulus of tissue-mimicking agar phantoms of various concentrations. Low-amplitude (micrometer scale) elastic waves were induced by a focused air-pulse delivery system and imaged by the respective systems. The Young’s modulus as assessed by both elastographic techniques was similar and was compared to the stiffness as measured by uniaxial mechanical testing. The results show that both techniques accurately quantified the elasticity. OCE can provide absolute elastic wave temporal profile, depth-resolved measurement and superior displacement sensitivity compared to LMV, but LMV is significantly cheaper (10X) and easier to implement than OCE.
Jiasong Li, Chih-Hao Liu, Alexander Schill, Manmohan Singh, Yury V. Kistenev, and Kirill V. Larin, "A comparison study of optical coherence elastography and laser Michelson vibrometry," Proc. SPIE 9710, Optical Elastography and Tissue Biomechanics III, 97101A (Presented at SPIE BiOS: February 15, 2016; Published: 9 March 2016); https://doi.org/10.1117/12.2213366.
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