We report two methods of surface enhanced Raman spectroscopy (SERS) for hemozoin detection in malaria infected human blood. In the first method, silver nanoparticles were synthesized separately and then mixed with lysed blood; while in the second method, silver nanoparticles were synthesized directly inside the parasites of Plasmodium falciparum.
Keren Chen, Aoli Xiong, Clement Yuen, Peter Preiser, and Quan Liu, "Investigation of surface enhanced Raman spectroscopy for hemozoin detection in malaria diagnosis," Proc. SPIE 9715, Optical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics, 97150F (Presented at SPIE BiOS: February 15, 2016; Published: 4 March 2016); https://doi.org/10.1117/12.2210804.
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