The vascularization and resulting perfusion of transferred tissues are critical to the success of grafts in buried free flap transplantations. To enable long-term clinical monitoring of grafted tissue perfusion during neovascularization and endothelialization, we are developing an implantable instrument for the continuous monitoring of perfusion using diffuse correlation spectroscopy (DCS), and augmented with diffuse reflectance spectroscopy (DRS). This work discusses instrument construction, integration, and preliminary results using a porcine graft model.
Noah J. Kolodziejski, Christopher J. Stapels, Daniel R. McAdams, Daniel E. Fernandez, Matthew J. Podolsky, Dana Farkas, Brent B. Ward, Mark Vartarian, Stephen E. Feinberg, Seung Yup Lee, Urmi Parikh, Mary-Ann Mycek, and James F. Christian, "A compact instrument to measure perfusion of vasculature in transplanted maxillofacial free flaps," Proc. SPIE 9715, Optical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics, 97150L (Presented at SPIE BiOS: February 16, 2016; Published: 4 March 2016); https://doi.org/10.1117/12.2212872.
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