Over the last 20 years, optical coherence tomography (OCT) has become a valuable diagnostic tool in ophthalmology with several 10,000 devices sold today. Other applications, like intravascular OCT in cardiology and gastro-intestinal imaging will follow. OCT provides 3-dimensional image data with microscopic resolution of biological tissue in vivo. In most applications, off-line processing of the acquired OCT-data is sufficient. However, for OCT applications like OCT aided surgical microscopes, for functional OCT imaging of tissue after a stimulus, or for interactive endoscopy an OCT engine capable of acquiring, processing and displaying large and high quality 3D OCT data sets at video rate is highly desired.
We developed such a prototype OCT engine and demonstrate live OCT with 25 volumes per second at a size of 320x320x320 pixels. The computer processing load of more than 1.5 TFLOPS was handled by a GTX 690 graphics processing unit with more than 3000 stream processors operating in parallel. In the talk, we will describe the optics and electronics hardware as well as the software of the system in detail and analyze current limitations. The talk also focuses on new OCT applications, where such a system improves diagnosis and monitoring of medical procedures. The additional acquisition of hyperspectral stimulated Raman signals with the system will be discussed.
Robert A. Huber, Wolfgang Draxinger, Wolfgang Wieser, Jan Philip Kolb, Tom Pfeiffer, Sebastian N. Karpf, Matthias Eibl, and Thomas Klein, "4D megahertz optical coherence tomography (OCT): imaging and live display beyond 1 gigavoxel/sec
(Conference Presentation)," Proc. SPIE 9720, High-Speed Biomedical Imaging and Spectroscopy: Toward Big Data Instrumentation and Management, 97200M (Presented at SPIE BiOS: February 14, 2016; Published: 28 June 2016); https://doi.org/10.1117/12.2212498.4848767890001.
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