In our study we aim to develop a new, simple and non-invasive method to detect and to treat atherosclerosis. We use gold nanoparticles (GNPs) combined with the diffusion reflection (DR) method to demonstrate the detection of vulnerable atherosclerotic plaques. Our method is based on the fact that macrophages are a major component in the vulnerable plaque and are able to uptake metal nanoparticles that can be discovered by the DR system. Moreover, it is well known that high density lipoprotein (HDL) reduces ASVD by inhibiting pro-inflammatory factors, enabling the specific treatment of atherosclerosis.
Rinat Ankri, Dorit Leshem-Lev, Eli I. Lev, Menachem Motiei, Edith Hochhauser, and Dror Fixler, "Gold nanoparticles based imaging technique and drug delivery for the detection and treatment of atherosclerotic vascular disease," Proc. SPIE 9721, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII, 97210F (Presented at SPIE BiOS: February 17, 2016; Published: 22 April 2016); https://doi.org/10.1117/12.2211401.
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