In addition to maintaining the structural integrity of the cell, the plasma membrane regulates multiple important cellular processes, such as endocytosis and trafficking, apoptotic pathways and drug transport. The modulation or tracking of such cellular processes by means of controlled delivery of drugs or imaging agents via nanoscale delivery systems is very attractive. Nanoparticle-mediated delivery systems that mediate long-term residence (e.g., days) and controlled release of the cargoes in the plasma membrane while simultaneously not interfering with regular cellular physiology would be ideal for this purpose. Our laboratory has developed a plasma membrane-targeted liquid crystal nanoparticle (LCNP) formulation that can be loaded with dyes or drugs which can be slowly released from the particle over time. Here we highlight the utility of these nanopreparations for membrane delivery and imaging.
Okhil K. Nag, Jawad Naciri, Christopher M. Spillmann, and James B. Delehanty, "Membrane-targeting liquid crystal nanoparticles (LCNPs) for drug delivery," Proc. SPIE 9722, Colloidal Nanoparticles for Biomedical Applications XI, 972215 (Presented at SPIE BiOS: February 15, 2016; Published: 22 April 2016); https://doi.org/10.1117/12.2212529.
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