Plasmonic biosensors have greatly overcome the limitations of conventional optical sensors in terms of sensitivity, tunability, photo-stability, and in vivo applicability. In this paper, we present plasmonic biosensors using bioenabled nanomaterials diatom biosilica, with active surface functionalities as affordable and eco-friendly integration platforms of Ag nanoparticles for label-free detection of biomolecules. Dual-mode plasmon sensing mechanisms, including surface-enhanced Raman scattering (SERS) and refractive-index (RI) sensing will be simultaneously implemented on the plasmonic-biosilica nanostructures to obtain quantitative biosensing with structural resolution of the biomolecules. We have achieved ultra-sensitive detection of Rhodamine 6G (R6G) at concentrations as low as 10−10 M. Furthermore, this substrate was used to detect TNT, illustrating the potential application as viable substrates for monitoring pollutant and toxics in environment.
Xianming Kong, Kenny Squire, Yuting Xi, Paul LeDuff, Gregory L. Rorrer, and Alan X. Wang, "Dual-mode bioenabled nano-plasmonic sensors for biological and chemical detection," Proc. SPIE 9725, Frontiers in Biological Detection: From Nanosensors to Systems VIII, 97250G (Presented at SPIE BiOS: February 15, 2016; Published: 22 April 2016); https://doi.org/10.1117/12.2214015.
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