The integration of optofluidic laser and FRET mechanism provides novel research frontiers, including sensitive biochemical analysis and novel photonic devices, such as on-chip coherent light sources and bio-tunable lasers. Here we investigated an optofluidic FRET laser using quantum dots (QDs) as FRET donors. We achieved lasing from Cy5 as the acceptor in the QD-Cy5 pair with excitation at 450 nm where Cy5 has negligible absorption by itself. The threshold was approximately 14 μJ/mm2. The demonstrated capability of QDs as the donor in a FRET laser greatly improves the versatility of optofluidic laser operation due to the broad and large absorption cross section of QDs in the blue and UV spectral region. The excitation efficiency of the acceptor molecules through FRET channel was also analyzed, showing that the energy transfer rate and the non-radiative Auger recombination rate of QDs plays a significant role in FRET laser performance.
Qiushu Chen, Alper Kiraz, and Xudong Fan, "An optofluidic FRET laser using quantum dots as donor," Proc. SPIE 9725, Frontiers in Biological Detection: From Nanosensors to Systems VIII, 97250I (Presented at SPIE BiOS: February 15, 2016; Published: 22 April 2016); https://doi.org/10.1117/12.2209722.
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