The optofluidic laser is an emerging technology that integrates microfluidics, miniaturized laser cavity, and laser gain medium in liquid. It is unique due to its biocompatibility, thus can be used for unconventional bioanalysis, in which biointeraction or process takes place within the optical cavity mode volume. Rather than using fluorescence, the optofluidic laser based detection employs laser emission, i.e., stimulated emission, as the sensing signal, which takes advantage of optical amplification provided by the laser cavity to achieve much higher sensitivity.
In this presentation, I will first introduce the concept of optofluidic laser based bioanalysis. Then I will discuss each of the three components (cavity, gain medium, and fluidics) of the optofluidic laser and describe how to use the optofluidic laser in bioanalysis at the molecular, cellular, and tissue level. Finally, I will discuss future research and application directions.
Xudong Fan, "Optofluidic lasers and their applications in bioanalysis
(Conference Presentation)," Proc. SPIE 9725, Frontiers in Biological Detection: From Nanosensors to Systems VIII, 97250J (Presented at SPIE BiOS: February 15, 2016; Published: 27 April 2016); https://doi.org/10.1117/12.2208772.4848770197001.
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