Prostate cancer causes one of the leading cancer-related deaths among the Caucasian adult males in Europe and the United State of America. However, it has a high recovery rate indicating when a proper treatment is delivered to a patient. There are cases of over- or under-treatments which exacerbate the disease states indicating the importance of proper therapeutic approach depending on stage of the disease. Recognition of the unmet needs has raised a need for stratification of the disease. There have been attempts to stratify based on biomarker expression patterns in the course of disease progression. To closely observe the biomarker expression patterns, we propose the use of quantitative imaging method by using fabricated quantum dot-based nanoprobe to quantify biomarker expression on the surface of prostate cancer cells. To characterize the cell line and analyze the biomarker levels, cluster of differentiation 44 (CD 44), prostate specific membrane antigen (PSMA), and epithelial cell adhesion molecule (EpCAM) are used. Each selected biomarker per cell line has been quantified from which we established a signature of biomarkers of a prostate cancer cell line.
Benedict J. Kang, Gun Hyuk Jang, Sungwook Park, and Kwan Hyi Lee, "Quantum dot nanoprobe-based quantitative analysis for prostate cancer
(Conference Presentation)," Proc. SPIE 9930, Biosensing and Nanomedicine IX, 99300O (Presented at SPIE Nanoscience + Engineering: August 30, 2016; Published: 3 November 2016); https://doi.org/10.1117/12.2237287.5164183653001.
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