From Event: SPIE Optical Engineering + Applications, 2016
Surface enhanced Raman scattering (SERS) is a popular technique for detecting and analyzing molecules at very low concentrations. The sensitivity of SERS is high enough to detect single molecules. It has proven difficult, however, to perform similar measurements in the so-called nonlinear optical regime, a regime in which the molecule is responding to multiple light pulses. Nonetheless, recent experiments indicate that after careful optimization, it is possible to generate signals derived from nonlinear analogs of SERS. Such measurements make it possible to view molecular vibrations in real time, which amounts to the femto- to pico-second range. In this contribution, we discuss in detail under which conditions detectable surface-enhanced coherent Raman signals can be expected, provide experimental evidence of coherent Raman scattering of single molecules, and highlight the unique information that can be attained from such measurements.
Eric O. Potma, Kevin Crampton, Alex Fast, Alba Alfonso García, and Vartkess A. Apkarian, "Coherent spectroscopy in the single molecule limit
(Conference Presentation)," Proc. SPIE 9956, Ultrafast Nonlinear Imaging and Spectroscopy IV, 99560A (Presented at SPIE Optical Engineering + Applications: August 28, 2016; Published: 2 November 2016); https://doi.org/10.1117/12.2237208.5170791526001.
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