From Event: SPIE Optical Engineering + Applications, 2016
The goal of this work is to develop and explore a novel small animal PET system that will advance our ability to detect, visualize, and quantify low concentrations of molecular probes. Key technologies of this work are:
(1) A superior performance cadmium zinc telluride (CZT) detector technology that uses solid-state semiconductor detectors, instead of scintillation crystals, to achieve ultra-high (≤ 1 mm3) resolution, 3-dimensional (3-D) event positioning and excellent energy resolution.
(2) A novel edge-on arrangement of these semiconductor crystals in a four-sided panel geometry that facilitates an order of magnitude greater photon detection efficiency.
The 3-D position sensitive dual-CZT detector module and readout electronics developed in our lab was scaled up to complete a significant portion of the final PET system. This sub-system was configured as two opposing detection panels containing a total of twelve 40 mm × 40 mm 5 mm monolithic CZT crystals for
proof of concept. System-level characterization studies, including optimizing the trigger threshold of each channel's comparators, were performed. 68Ge and 137Cs radioactive isotopes were used to characterize the energy resolution of all 468 anode channels in the sub-system. The mean measured global 511~keV photopeak energy resolution over all anodes was found to be 7.35±1.75% FWHM after correction for photon interaction depth-dependent signal variation. The measured global time resolution was 24~ns FWHM after precise time caibration, and the intrinsic spatial resolution was 0.76~mm FWHM.
Shiva Abbaszadeh and Craig Levin, "Design and optimization of a new-generation CZT-based positron emission tomography system
(Conference Presentation)," Proc. SPIE 9969, Radiation Detectors: Systems and Applications XVII, 99690F (Presented at SPIE Optical Engineering + Applications: September 01, 2016; Published: 2 November 2016); https://doi.org/10.1117/12.2241734.5178382302001.
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