Prolonged cardiopulmonary bypass (CPB) exposure and excessive anticoagulation during cardiac surgical procedures frequently cause acute bleeding. Here we investigated the accuracy and precision of a novel optical sensor, iCoaglab, that utilizes a small volume of whole blood to comprehensively monitor blood coagulation in patients. Our results showed coagulation metrics, activated clotting times (ACT), maximum clot stiffness (MA), and fibrinolysis were highly correlated with standard-reference tests. In conclusion, iCoaglab uniquely affords comprehensive profiling of whole blood coagulation, potentially enabling the capability to identify coagulation impairments and predict bleeding during CPB.

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Ziqian Zeng, Pablo Gonazalez Polanco, Zeinab Hajjarian Kashany, Diane M. Tshikudi, and Seemantini K. Nadkarni, "Multifunctional coagulation profiling for cardiac surgical interventions at the point-of-care," Proc. SPIE PC12355, Diagnostic and Therapeutic Applications of Light in Cardiology 2023, PC1235508 (Presented at SPIE BiOS: January 28, 2023; Published: 17 March 2023); https://doi.org/10.1117/12.2656167.6321335848112.