From Event: SPIE BiOS, 2023
Although immunotherapy, including immune checkpoint inhibitors, has revolutionized cancer treatment, only a small percentage of patients show sustained response. Recently, we have shown that photobiomodulation (PBM) with near-infrared (NIR) light in the NIR-II window reduces oxidative stress and supports CD8+ T cell proliferation, suggesting that PBM with NIR-II light may enhance anticancer immunity. In this study, we report a novel approach to support tumor-infiltrating CD8+ T cells by PBM using NIR-II laser with high tissue penetration depth. Lasers are a safe and low-cost therapy that can be used in combination with a broad range of other therapies without modification.
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Shinya Yokomizo, Wataru Katagiri, Takanobu Ishizuka, Keiko Yamashita, and Satoshi Kashiwagi, "Dual near-infrared II laser modulates the cellular redox state of T cells and augments the efficacy of cancer immunotherapy," Proc. SPIE PC12358, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2023, PC1235808 (Presented at SPIE BiOS: January 28, 2023; Published: 17 March 2023); https://doi.org/10.1117/12.2656197.6321337669112.