From Event: SPIE BiOS, 2023
Pre-clinical research is often conducted in two-dimensional (2D) cancer cell cultures or in animal models to identify the molecular pathways that underlie the onset and course of a disease or to assess the effectiveness of experimental therapies. However, the reductionist 2D method may distort interactions between cells and integrins and does not recreate 3D cell morphology or match the natural in situ environment of tissues. Despite the fact that animal models offer the natural 3D milieu in which cells reside, interspecies differences, cost, and ethical concerns continue to be important barriers to the development of these models. Therefore, there is a critical need for creating bioengineered in vitro models that can use biomaterials and cells obtained from humans to replicate the 3D cytostructure and microenvironment of diseases. In this talk, I will give an overview of our work on microphysiological tissue models for drug screening in this lecture. To this end, I will discuss the c
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Mohsen Akbari, "Engineered microtissues for disease modelling and drug screening," Proc. SPIE PC12374, Microfluidics, BioMEMS, and Medical Microsystems XXI, PC1237408 (Presented at SPIE BiOS: January 30, 2023; Published: 6 March 2023); https://doi.org/10.1117/12.2657740.6321580546112.