Measuring cancer cell response to therapy is an essential component of developing new therapies or determining the optimal treatment for a particular patient. In this talk I will discuss the use of quantitative phase imaging (QPI) to measure the distribution of mass within single cells, and how this distribution changes over time. Based on this approach, my lab has developed new approaches to quantify the time-dependence and intracellular spatial distribution of cell response to small-molecule inhibitors. These data can be used to study basic cell physiology, as well as how cancer cells respond to therapies.

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Thomas A. Zangle, "Quantitative phase imaging to quantify cell growth and response to therapy in space and time (Conference Presentation)," Proc. SPIE PC12389, Quantitative Phase Imaging IX, PC123890S (Presented at SPIE BiOS: January 30, 2023; Published: 16 March 2023); https://doi.org/10.1117/12.2656156.6321657746112.