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7 March 2022 Shot-noise limited tunable dual-band light source for stimulated Raman scattering microscopy and histology
Ingo Rimke, Sandro Heuke, Barbara Sarri, Paulina Gasecka, Romain Appay, Peter Volz, Edlef Büttner, Hervé Rigneault
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Proceedings Volume PC11957, Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry; PC119570R (2022) https://doi.org/10.1117/12.2608666
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
We present a shot noise limited, three-color SRS implementation to address two molecular vibrations simultaneously. The system allows fast, high quality stimulated Raman histology as well as background-free SRS imaging. It is ready to be tested in hospitals for its viability and image quality in comparison to classical rapid histology. It is based on a mode-locked fs-laser from which 2 narrow-band Stokes laser beams are extracted and subsequently modulated at 13 and 20MHz. The center part of the fs-laser is frequency doubled to pump a picosecond optical parametric oscillator, which can be tuned from 500 to 5000 cm−1.
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Ingo Rimke, Sandro Heuke, Barbara Sarri, Paulina Gasecka, Romain Appay, Peter Volz, Edlef Büttner, and Hervé Rigneault "Shot-noise limited tunable dual-band light source for stimulated Raman scattering microscopy and histology", Proc. SPIE PC11957, Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry, PC119570R (7 March 2022); https://doi.org/10.1117/12.2608666
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KEYWORDS
Microscopy
Raman scattering
Optical parametric oscillators
Raman spectroscopy
Picosecond phenomena
Light sources
Microscopes
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